- The solubility of HPMC in ethanol is generally lower than in water, primarily because of the weaker hydrogen bonding between the cellulose ether chains and ethanol molecules. This characteristic makes HPMC-ethanol solutions less viscous compared to those in water, influencing its use in formulations where low viscosity is desired.
Potential side effects:
- The ability of HPMC to dissolve in organic solvents is exploited in a number of applications. In the pharmaceutical industry, HPMC is often used as a film-forming agent in tablets and capsules. The polymer can also be used as a thickening agent in liquid formulations, providing viscosity control and stability. In the food industry, HPMC is used as an emulsifier and stabilizer in various products, including ice cream, salad dressings, and sauces.
- One of the primary functions of HPMC is its ability to act as a thickening agent. When added to liquids, it increases their viscosity without altering their taste or color. This makes it an ideal choice for a wide range of applications, including food, pharmaceuticals, and cosmetics. In the construction industry, HPMC is used as an additive in paints and coatings, where it helps to improve their adherence to surfaces and reduce cracking and peeling.
- In the paint and coatings industry, Ashland HEC is used as a thickener and rheology modifier in water-based formulations
ashland hydroxyethyl cellulose. It helps to improve the flow and leveling of the paint, making it easier to apply and ensuring a smooth and even finish. HEC also enhances the adhesion of the paint to the surface, helping to improve its durability and longevity. - Overall, having access to the HPMC contact number is essential for anyone seeking information or assistance related to the company's products or services. By calling this number, customers can quickly and easily connect with a knowledgeable representative who can help them resolve any issues or answer any questions they may have.
- Some of the leading HPMC manufacturers in the market include Ashland, Dow Chemical, and Hercules. These companies have a strong reputation for producing high-quality HPMC and meeting the strict requirements of various industries.
- Hydroxypropyl Methylcellulose's meaning extends beyond its chemical name; it embodies a range of properties that make it a widely used ingredient. In pharmaceuticals, HPMC serves as an excipient, used in tablet coatings and as a binder in capsules due to its ability to form a gel when mixed with water. This property ensures controlled drug release, enhancing the medication's efficacy.
The etherification of cellulose disrupts the hydrogen bonding and the resulting compounds are not ionised and more water soluble. The EFSA ANS Panel (2018) concluded that modified celluloses including ethyl and methyl, hydroxypropyl celluloses, would not be absorbed intact and not fermented in the gastrointestinal tract of animals (rat) or humans; they are excreted essentially unchanged mainly via the faeces (more than 90% of the administrated doses), while only minor amounts of metabolites and derived-products are excreted via urine or expired air (as 14CO2) and there is no indication for accumulation in the body.

hpmc thickener.
Answer: HPMC cold water instant type is after glyoxal surface treatment, in cold water quickly dispersed, but not the real dissolution, viscosity is dissolved. The hot soluble type has not been surface treated with glyoxal. The amount of glyoxal is large, the dispersion is fast, but the viscosity is slow, the amount is small, the opposite.



hydroxyethyl cellulose thickening mechanism. Additionally, HEC solutions are temperature-dependent, with higher temperatures leading to a decrease in viscosity due to the weakening of hydrogen bonds between the polymer chains.
For hydroxypropyl cellulose (E 463), the identified NOAEL corresponded to the highest dose 6,000 mg hydroxypropyl cellulose/kg bw per day (by gavage). The most relevant feeding studies with HPMC (E 464) were performed in rats which tolerated up to 10%, corresponding to 9,000 mg test item/kg bw per day. Rabbits tolerated up to 7,500 mg HPMC/kg bw per day administered via the diet (30 day exposure) and dogs up to 1,500 mg HPMC/kg bw per day, in either case being the highest tested dosages. More studies were conducted using sodium carboxy methylcellulose (E 466). The most relevant ones were conducted in rats, with NOAEL values ranging from 4,500 to 9,000 mg test item/kg bw per day (in all cases the highest dose tested). In these studies, some effects (caecum and colonic enlargement, urothelial hyperplasia, nephrocalcinosis, diffuse epithelial hyperplasia in the urinary bladder) were observed, however, not considered of toxicological concern: the findings in the gastrointestinal tract were considered to be a consequence of the accumulation of poorly absorbed water-soluble material and the findings in kidneys and urinary bladder were attributed to the up to fourfold higher concentration of sodium in the test diet compared with the basal diet. In one further study, rats were daily exposed (gavage) to doses equivalent to 0, 500, 2,500 or 5,000 mg/kg bw per day. Animals treated with ≥ 2,500 mg/kg bw per day had soft and pale faeces, which was attributed to the presence of test material and not considered of toxicological relevance. In the absence of any other adverse effects, also for this study, the identified NOAEL was the top dose (5,000 mg/kg bw per day).